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background behind the research

Taking Neutrophils to their Limit

• Neutrophils, a type of immune cell, are well known for their role in fighting pathogens
• In addition, neutrophils have been found to be involved in many inflammatory disorders such as in arthritis, certain cancers, diabetes, and even in responses against biomaterial implants

Questions we ask about their roles include:
1. How quickly are they produced by the body in response to an inflammatory stimulus?
2. What happens when the body faces two inflammatory disorders simultaneously?
3. How do opportunistic pathogens overcome neutrophil action?

Ultimate Goal:
Contribute towards understanding neutrophil actions in diseased conditions so new therapeutics may be developed.

Time-frame: Basic research with open goals and time-frames.

Vision: To create and enable technologies
that solve clinical problems associated with
immune responses
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Recent Posts

29. A biomaterial implant model demonstrates that immature neutrophils drive immunopathology following acute injury.

28. Phenomenological modeling of gene transcription by approximating cooperativity of transcription factors improves prediction and reduces complexity in gene regulatory network models.

Contact Info

  • Department of Bioengineering
  • LG-02 TCS Smart-X Hub Building
  • Indian Institute of Science (IISc)
  • Bengaluru, India – 560012
  • siddharth [at] iisc [dot] ac [dot] in
  • +91 80 22932452

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