IMMUNOENGINEERING LAB

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background behind the research

Innate Immune Cells

• Innate immune cells play important roles in many other conditions and diseases.
• We explore their phenotype and function in a number of different conditions.

Gliomas
• A number of immune cells are present in gliomas, but they are either inactive or immunosuppressive, and hence are unable to kill the cancer cells.
• We have been collaborating with clinicians and researchers at Mazumdar-Shaw Center for Translational Research (https://www.msctr.org/2016/09/16/dr-nameeta-shah/ ) to characterize the suppressive immune cells present in brain tumors.
• The ultimate goal of this project is to understand if specific immune cells may be targeted for treatment of gliomas.

Fibrosis of biomaterial implants
• Neutrophils and monocytes are involved in fibrosis of biomaterial implants.
• Bacterial infections are also known to develop around biomaterial implants. • One question that interests us is how do immune cells interact with bacteria next to a biomaterial implant? • Using neutrophils and staphylococcus model systems, we explore this question both in vitro and in vivo.
Ultimate Goal:
To develop immuno-modulatory drug delivery systems that improve the capacity of macrophages and neutrophils to fight off microbial pathogens.
Time-frame: 5 – 10 years
Vision: To create and enable technologies
that solve clinical problems associated with
immune responses
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Recent Posts

20. Cholesterol Levels and Monocyte Phenotype are Predictors of Non-healing in Individuals with Low Grade Diabetic Foot Ulcers: A Prospective Cohort Study

19. Sterile Inflammation Alters Neutrophil Kinetics in Mice.

Contact Info

  • Indian Institute of Science
  • Centre for BioSystems Science and Engineering
  • IISc, Bengaluru - 560012
  • siddharth [at] iisc [dot] ac [dot] in
  • +91 80 22932452

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